研究刺梨汁高、中、低剂量组对链脲佐菌素（STZ）诱导形成Ⅰ型糖尿病小鼠的降糖效果。将造模成功后的小鼠随机分为模型组、阳性组、刺梨汁高、中、低剂量组，并设空白对照组。灌胃给药，期间测定小鼠的饮食饮水量、体重、空腹血糖（FBG）、糖耐量、糖化血清蛋白（GSP）、糖化血红蛋白（GHb）、血清胰岛素（INS）、肝糖原以及脏器指数变化。连续灌胃治疗28 d后，多饮多食的症状明显好转，体重下降受到抑制；与模型组相比，刺梨汁高、中、低剂量组的FBG分别下降了39.80%、18.18%、7.18%；GHb降低了29.85%、16.04%、10.52%；GSP降低了18.52%、9.80%、6.32%；INS分别升高了26.13%、20.60%、14.21%；血糖时间曲面下的面积（AUC）分别降低44.43%、22.62%、14.07%，肝糖原分别增加了1.39、1.10和1.02倍，表明刺梨汁对Ⅰ型糖尿病小鼠具有辅助治疗作用。

The hypoglycemic effect of Roxburghii juice in high, middle and low dose groups on streptozotocin (STZ) -induced type I diabetic mice was studied. The mice were randomly divided into blank group, model group, positive group, high, middle and low dose groups administration by gavage for 4 weeks. Changes in diet and water intake, body weight, fasting blood glucose (FBG), glucose tolerance, glycosylated serum protein (GSP), glycosylated hemoglobin (GHb), serum insulin (INS), liver glycogen and organ index were measured during the study. After continuous gavage for 28 days, the symptoms of polydipsia and polyphagia were significantly improved and weight loss was inhibited. Compared with the model group, FBG in the high, medium and low dose groups of Rosa roxburghii juice decreased by 39.80%, 18.18% and 7.18%, respectively. GHb decreased by 29.85%, 16.04% and 10.52%. GSP decreased by 18.52%, 9.80% and 6.32%. INS increased by 26.13%, 20.60% and 14.21% respectively, the areas under the blood glucose time curve (AUC) were reduced by 44.43%, 22.62% and 14.07%, respectively, liver glycogen levels were increased by 1.39, 1.10 and 1.02 times, respectively, show that thorn pear juice have auxiliary therapy effect on theⅠdiabetes mice.

贵州省重大科技专项（黔科合重大专项字[2013]6006-2）