本研究拟通过动物实验，探讨实验室自制樟芝口服液的解酒护肝效果。实验对比了不同组小鼠摄入樟芝口服液后，其醉酒耐受时间与醉酒时间，血清中谷丙转氨酶、谷草转氨酶水平及肝组织匀浆中乙醇脱氢酶、乙醛脱氢酶水平。结果表明，高剂量樟芝口服液能显著延长小鼠醉酒耐受时间，从14.1±5.2 min延长到27.9±7.9 min，缩短了醉酒时间，从230.0±22.3 min缩短至161.7±38.0 min，能显著降低因酒精损伤而导致血清中谷丙转氨酶和谷草转氨酶水平的升高，分别从56.34±9.60 U/L、69.57±11.88 U/L降低到42.35±12.29 U/L和51.86±15.04 U/L；同时提高了乙醇脱氢酶和乙醛脱氢酶活性，分别从6.21±1.91 U/mg prot、454.15±119.18 U/mg升高到9.82±3.36 U/mg prot和454.15±119.18 U/mg。说明实验室自制樟芝口服液具有一定的解酒护肝功效。

Antrodia camphorata has a variety of beneficial physiological activities, this study is intended to through animal experiments to explore the antialcoholism effects and liver protection of laboratory homemade Antrodia camphorata oral Liquid. Compared with the tolerance time and drunken time, the levels of serum alanine aminotransferase and aspartate aminotransferase, the levels of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver homogenates in different groups of mice, it was found that the high-dose Antrodia camphorata oral liquid could significantly prolong the time of intoxication tolerance in mice, from 14.1 ± 5.2 min to 27.9 ± 7.9 min, shorten the time of intoxication from 230.0±22.3 min to 161.7±38.0 min. It can significantly reduce serum aspartate aminotransferase and alanine aminotransferase caused by alcohol injury, from 56.34±9.60 U/L to 42.35±12.29 U/L and 69.57±11.88 U/L to 51.86±15.04 U/L, respectively. It could also further increase of the level of alcohol dehydrogenase and acetaldehyde dehydrogenase, from 6.21±1.91 U/mg prot to 9.82±3.36 U/mg prot and 454.15±119.18 U/mg to 454.15±119.18 U/mg, respectively. It shows that the homemade oral liquid has anti-alcohol and liver protection effects.

国家自然科学基金项目（31501476、31660459）；江苏省自然科学基金（BK20150139）；佛山市科技局项目（2016AB000011、2016GA10155、2017AB004081）