本文研究野生猕猴桃与维生素C对大鼠酒精肝脑损伤的预防性保护作用。将40只雄性SD大鼠随机分为4组：正常组、模型组、维生素C组及野生猕猴桃组。正常组给予等量生理盐水，其余组灌胃56 °红星二锅头建立酒精肝脑损伤模型（第一周剂量为8 mL/kg，第二周为10 mL/kg），每天1次，同时正常组、模型组给予普通饲料，维生素C组给予维生素C强化饲料（按420 mg/kg添加维生素C），野生猕猴桃组给予按30%比例添加野生猕猴桃的饲料。2周后检测大鼠肝功能、肝脂质含量和氧化应激水平，HE染色观察肝和脑病理变化。结果表明，与模型组比较，野生猕猴桃与维生素C可显著降低酒精肝脑损伤大鼠的血清ALT、AST、TG、TC、LPO，血清及脑MDA，升高血清及脑SOD（p<0.01），野生猕猴桃降低或升高指标更显著（p<0.05）。因此，野生猕猴桃和维生素C对酒精肝脑损伤均具有预防性保护作用，前者效果更好。

The preventive protective effects of wild kiwifruit and pure vitamin C on alcoholic liver and brain injury in rats were investigated in this study. 40 male SD rats were randomly divided into four groups: normal group, model group, vitamin C group and wild kiwifruit group. The normal group was given the same amount of normal saline, and other groups were given 56°Red Star Erguotou by gavage to establish the alcoholic liver and brain injury model(8 mL/kg for first week, and 10 mL/kg for the second week once a day). The normal group and the model group were given the common feed. The wild kiwifruit group was fed with 30% concentration of wild kiwifruit, and the vitamin C group was given vitamin C-fortified feed (420 mg/kg). The liver function, liver lipid content and oxidative stress level were measured after two weeks, and pathological changes of liver and brain were observed by HE staining. Results showed that compared with the model group, wild kiwifruit and vitamin C could significantly reduce alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride(TG), total cholesterol (TC), lipid peroxidation (LPO), malondialdehyde (MDA) in serum, and increase superoxide dismutase(SOD) in serum and brain homogenate (p<0.01). In addition, the decrease and increase indexes were even more significant in wild kiwifruit group (p<0.05). Consequently, wild kiwifruit and vitamin C had preventive protection effects on alcoholic liver and brain injury, and the former had the better effects.

国家级大学生创新创业训练计划项目（201610632002）；西南医科大学-宜宾县人民政府合作项目基金（2014YDHZ-005）