本文研究了桑叶超微粉奶茶的降血脂作用，为辅助降糖、降血脂保健食品的研发提供参考。采用四氧嘧啶造糖尿病小鼠模型，给造模成功小鼠灌胃不同剂量的桑叶超微粉奶茶，探讨桑叶超微粉奶茶对糖尿病小鼠体重的影响，同时测定小鼠血清的相关血脂指标。结果显示，喂饲桑叶超微粉奶茶后糖尿病小鼠体重增长缓慢症状得到有效改善，雌鼠和雄鼠体重增长率达37.11%和40.99%；灌胃不同剂量的桑叶超微粉奶茶后，糖尿病小鼠的TC、TG和LDL-C值均显著降低，下降率分别可达到17.52%，48.13%，2.47%，HDL-C值升高46.81%。表明桑叶超微粉奶茶具有缓解糖尿病小鼠体重消瘦症状的作用，桑叶超微粉奶茶具有一定的辅助降血脂作用，桑叶超微粉奶茶对不同性别糖尿病小鼠降血脂的作用机制、最佳摄入量还有待进一步研究，期望本研究能够为相关保健食品的开发提供参考建议。

In this study, the hypolipidemic effect of mulberry leaf ultrafine milk tea was investigated to provide reference for the research and development of hypoglycemic and hypolipidemic health food. The effect of mulberry leaf ultrafine milk tea on the body weight and serum lipid related indicators of diabetic mice were investigated by intragastric administration of mulberry leaf ultrafine milk tea with different dosages to the diabetic mice modeled by alloxan. The results showed that the slow growth of body weight in diabetic mice was significantly improved after the feeding of mulberry leaf ultrafine milk tea, and the weight growth rates of female mice and male mice were 37.11% and 40.99%, respectively. After oral administration of the mulberry leaf ultrafine milk tea with different dosages, the levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in diabetic mice were significantly decreased by 17.52%, 48.13% and 2.47% respectively, and the high density lipoprotein cholesterol (HDL-C) level was increased by 46.81%. The results showed that mulberry leaf ultrafine milk tea could alleviate the weight loss symptoms of diabetic mice, and the mulberry leaf ultrafine milk tea had certain hypolipidemic effect. The mechanism of hypoglycemic effect of mulberry leaves superfine milk tea on diabetic mice of different genders and the best intake remain to be further research, and it is expected that the study will be able to provide reference for the development of related health food.

国家级大学生创新创业训练计划项目（201610635079）；现代农业产业技术体系建设专项（CARS-22）