本文研究了桑叶-苦瓜混合粉对糖尿病小鼠血脂的影响，为糖尿病降血脂保健食品的开发利用提供依据。通过建立糖尿病小鼠模型，饲喂基础饲料或高脂饲料的同时灌胃不同剂量的桑叶-苦瓜混合粉，30 d后摘眼球取血，测定小鼠血清中与脂代谢有关生化指标的变化。结果表明灌胃0.5 mL、0.20 g/mL桑叶-苦瓜混合粉时，与模型对照组相比，饲喂基础饲料和高脂饲料的糖尿病小鼠的TC、TG和LDL-C水平均显著或极显著的低于模型对照组；HDL-C水平均显著或极显著的高于模型对照组，饲喂基础饲料组的雌雄小鼠TC值分别下降14.58%和18.45%；TG值分别下降20.57%和21.98%；LDL-C值分别下降57.14%和57.41%；HDL-C值分别上升96.97%和95.45%，其各项血脂值趋于正常值.。所以在控制饮食的同时摄入一定量的桑叶-苦瓜混合粉，可对糖尿病小鼠起到良好的降血脂效应。

This study aimed to investigate the effect of mulberry leaf and balsam spear mixed powder on blood lipid metabolism in diabetic mice, and provide a reference for the development and utilization of healthy food with hypoglycemic and antidiabetic activities. A mouse model of diabetes mellitus was established, and the animals were fed a basal or high-fat diet along with different doses of mulberry leaf and balsam spear mixed powder. Blood samples were collected 30 d later to measure changes in the serum biochemical indices related to lipid metabolism in the mice. The results showed that when the mice were fed 0.5 ml of 0.20 g/mL mulberry leaf and balsam spear mixed powder solution, the levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in the diabetic mice fed with basal or high-fat diets were significantly lower than those in the control group (p<0.05). In addition, the high-density lipoprotein cholesterol (HDL-C) levels were significantly higher than that of the control group. For female and male mice fed the basal diet, LDL-C values decreased by 57.14% and 57.41%, respectively; HDL-C values increased by 96.97% and 95.45%, respectively; TC values decreased by 14.58% and 18.45%, respectively; and TG values decreased by 20.57% and 21.98%, respectively. All values of blood lipid indicators tended to be close to normal values. Therefore, the intake of mulberry leaves-bitter gourd mixed powder with diet control can have a beneficial hypolipidemic effect in diabetic mice.

国家现代农业（桑蚕）产业技术体系建设专项（CARS-22-ZJ0503）