探讨桑椹多糖对急慢性酒精中毒小鼠的护肝作用。给药4周后测定急性酒精中毒小鼠醉酒时间，血中乙醇浓度，肝功能酶，肝中氧化酶、氧化产物和脂肪的分布。给药10周后测定慢性中毒小鼠的自发活动次数，血清中脂质、载脂蛋白和肝中一氧化氮及细胞因子的含量。结果表明桑椹多糖（400和200 mg/kg bw）可显著缩短急性酒精中毒小鼠的醉酒睡眠与醒酒时间、血中乙醇浓度，延长醉酒潜伏期，减少肝中丙二醛和甘油三脂的含量与脂滴的分布，增加肝中谷胱甘肽的含量与超氧化物歧化酶的活性，减少血清中谷丙转氨酶、谷草转氨酶、血清碱性磷酸酶及谷胺酰转移酶的活性；显著减少慢性酒精中毒小鼠的自发活动次数、血中胆固醇、甘油三脂、低密度脂蛋白和肝中一氧化氮、肿瘤坏死因子α的含量，增加血中高密度脂蛋白与肝中白细胞介素10的含量。桑椹多糖对急慢性酒精中毒小鼠的肝功能有保护作用。

In order to explore the hepatoprotective effects of Fructus mori Polysaccharide (FMP) on mice with acute and chronic alcoholism. Inebriation time, blood alcohol concentration, liver function enzymes, oxidase, oxidation products, and fat distribution in the liver were measured in mice with acute alcoholism after continuous FMP administration for 4 weeks. The number of spontaneous activities, serum lipids, apolipoproteins, nitric oxide (NO), and cytokine content in the liver were measured or observed in mice with chronic alcoholism after continuous FMP administration for 10 weeks. The results showed that high and moderate doses of FMP (400 and 200 mg/kg bw) significantly reduced inebriated sleep time, sobering time, and blood alcohol concentration, and significantly extended inebriation latency in mice with acute alcoholism. Malondialdehyde (MDA) and triglyceride (TG) contents and the distribution of lipid droplets in the liver were significantly decreased upon FMP administration at these doses. In addition, reduced glutathione (GSH) content and superoxide dismutase (SOD) activity were significantly increased, and the activity of alanine transaminase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT) in serum were significantly reduced. FMP significantly reduced spontaneous activity, the content of cholesterol (TC), TG, blood low-density lipoprotein (LDL), NO content, and tumor necrosis factor-α (TNF-α) level in livers of mice with chronic alcoholism. Serum high density lipoprotein (HDL) and interleukin-10 (IL-10) in the liver were significantly increased. Fructus mori polysaccharide had a significant hepatoprotective effect on mice with acute and chronic alcoholism.

湖南省重点学科建设项目资助（2011-76）；湖南省高校科技创新团队支持计划资助（2012-318）；湖南省教育厅项目资助（11C0973）；湖南中医药管理局项目资助（2013FJ3004）