[关键词]
[摘要]
以茶树品种金萱的鲜叶新梢为原料,通过杀青、烘干、脱色、去除木质素与半纤维素,干燥粉碎后制得纤维素,然后用1-烯丙基-3-甲基咪唑盐酸盐作为溶剂,用加热搅拌方法制备出水凝胶。通过傅立叶红外光谱扫描、扫描式电子显微镜观察与质构分析等方法对水凝胶进行表征,并研究了水凝胶的平衡润胀率,用水杨酸钠作为模型药物分子的平衡载药率和释放率。实验发现:不同嫩度的茶叶纤维及其水凝胶在结构上差异较小;水凝胶在制备过程中,对应的纤维素均与离子液体发生了相互作用,产生的水凝胶主要组成属于再生纤维;叶梗水凝胶的凝胶特性、质构特性在5组样品中最优;二叶纤维所制备的水凝胶的平衡润胀率最高;而对水杨酸钠的平衡载药率与释放率则以成熟叶纤维制备的水凝胶最高。
[Key word]
[Abstract]
Cellulose samples were prepared from fresh Jinxuan tea shoots by fixing, drying, discoloration, removal of lignin and hemicellulose, grinding, heating, and stirring to prepare hydrogels with 1-allyl-3-methylimidazolium chloride as the solvent. Characterization of the prepared celluloses and hydrogels was performed by Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEC), and texture profile analysis (TPA). The equilibrium swelling degree of the hydrogels as well as the equilibrium drug loading and releasing rates were studied with sodium salicylate as the model drug molecule. The results showed slight differences in the structures of celluloses and hydrogels prepared from tea shoots with different maturity levels. During the preparation of hydrogels, the corresponding celluloses reacted with the ionic liquid and the main component of the prepared hydrogels was regenerated cellulose. The hydrogel prepared from the stems showed optimum gel and texture properties among the five groups of samples analyzed. The hydrogel prepared from the second leaf of young buds exhibited the highest equilibrium swelling degree, followed by that prepared from the stem. The highest equilibrium drug loading and releasing rates of sodium salicylate were present in the hydrogel prepared from mature leaves.
[中图分类号]
[基金项目]
高等学校博士学科点专项科研基金资助项目(20120172110017);国家自然科学基金资助项目(31471673,31271978)