对D-半乳糖致衰老小鼠分别灌胃添加茶新菇多糖或真姬菇多糖的益生菌酸奶，研究两种真菌多糖酸奶对小鼠抗皮肤衰老作用的协同效果。结果显示，皮肤组织经HE染色观察，衰老组小鼠皮肤发生病变，而高剂量组小鼠皮肤修复效果最佳。两种真菌多糖益生菌酸奶均可显著提高小鼠皮肤中SOD活性及含水量，降低MDA含量，提高皮肤和尾腱中HYP含量（p<0.05），且与多糖添加量呈剂量增强效应。与衰老组相比，茶新菇多糖酸奶和真姬菇多糖酸奶高剂量组小鼠皮肤中SOD活力提高了66.31%、14.54%，含水率提高16.49%、8.93%，皮肤和尾腱中羟脯氨酸含量分别提高48.27%、65.59%和73.98%、61.63%，MDA含量降低38.96%、45.64%，皮肤抗衰老指标极显著改善（p<0.01）。结论：两种真菌多糖均可与益生菌酸奶在皮肤抗衰老方面发挥显著协同作用，有效修复皮肤损伤。

To investigate the synergistic anti-aging effect of probiotic yogurt containing Agrocybe aegerita polysaccharides (AAP) or Hypsizigus marmoreus polysaccharides (HMP) on the skin, D-galactose-induced aging mice were fed two yogurt samples by gavage and the skin tissues were examined by hematoxylin and eosin staining. The results showed that skin lesions occurred in the aging group and that the optimum skin repair effect occurred in the high dose group. Both AAP yogurt and HMP yogurt significantly increased superoxide dismutase activity and moisture content, reduced malondialdehyde content in the mouse skin, and improved hydroxyproline (HYP) content in the tail tendon (P < 0.05); additionally, both samples showed a dose enhancement effect with the amount of added polysaccharides. Compared to the aging model group, the superoxide dismutase activity levels in the mouse skin of the high-dose AAP yogurt and HMP yogurt groups were increased by 66.31% and 14.54%, respectively; moisture content was increased by 16.49% and 8.93%, respectively; HYP content in the skin was increased by 48.27% and 65.59%, respectively; HYP content in the tail tendon was increased by 73.98% and 61.63%, respectively; malondialdehyde content was reduced by 38.96% and 45.64%, respectively. The skin anti-aging indices were significantly improved (P < 0.01). In conclusion, both AAP and HMP polysaccharides have a significant synergistic effect on skin anti-aging activity with probiotic yogurt and can effectively repair damaged skin.