随着社会经济的发展和人们生活水平的提高，原有的饮食习惯逐步发生改变，便秘这一影响现代人生活质量的常见疾病越来越受到重视，因此寻找安全有效的润肠通便产品显得十分重要。本文研究一种中草药组方保健食品的润肠通便功能。采用复方地芬诺酯建立小鼠便秘模型，通过小鼠小肠推进实验和排便实验，检测小鼠的首次排便时间、5h 内排便粒数、排便重量、小肠墨汁推进率，以及对小鼠结肠P物质（SP）、血管活性肠肽（VIP）和小鼠突触素（SY）的影响。研究发现：与便秘模型组相比，中草药组分保健食品各剂量组都能缩短复方地芬诺酯小鼠的排便时间，增加5小时小鼠排出的粪便粒数和重量，提高复方地芬诺酯小鼠的墨汁推进率，促进小鼠的肠胃蠕动，提高小鼠的SP值，降低VIP值。结果表明，研究的中草药组方保健食品具有较好的润肠通便作用。

With development of the social economy and improvement of people’s standard of living, traditional dietary habits have been gradually changing. Consequently, constipation, a common disease affecting quality of life, has attracted considerable attention. Therefore, it is very important to discover safe and effective products that can improve bowel movement. This study aims to evaluate the functional action of a Chinese herbal compound in improving bowel movement. A mouse model of constipation induced using diphenoxylate was used in small intestinal motility and bowel evacuation experiments. Measurements included the first evacuation time, the number of fecal pellets in five hours, the weight of evacuation, the movement rate of ink in the small intestine, and the effect of the herbal compound on colonic substance P (SP), vasoactive intestinal peptide (VIP), and synaptophysin (SY). The results showed that compared with the control group, the groups treated with the Chinese herbal compound exhibited a shortened evacuation time, an increased number of fecal pellets, an increased weight of feces in five hours, an increased movement rate of ink, an enhanced small intestinal movement, an increased SP value, and a decreased VIP level. Therefore, the results demonstrate that the Chinese herbal compound can improve bowel movement in mice.

广东省自然科学基金（2014A030313242）