本文研究了黑木耳对铅中毒大鼠的促排铅作用。采用预防性高铅大鼠模型分别进行黑木耳促排铅试验和黑木耳提取物促排铅试验，分析黑木耳排铅试验各组中血铅、脑铅、肝铅、肾铅、骨铅、尿铅和粪铅含量及清除率，以及黑木耳不同提取物排铅试验各组中血铅、脑铅、肝铅、肾铅、骨铅、尿铅和粪铅含量及清除率。经统计学分析发现，黑木耳能显著降低铅中毒大鼠中骨铅、血铅、肝铅、肾铅和脑铅的含量（P<0.05），平均清除率依次为28.61%、59.94%、59.64%、15.84%、29.41%。黑木耳乙醇提取物能显著降低血铅含量（清除率为63.47%），使尿铅排出量增加（清除率为-55.45%）；水提取物粪铅排出量显著增加（清除率为-26.60%）；提取物残渣能显著降低骨铅、肝铅、肾铅和脑铅含量（清除率分别为49.82%、74.21%、74.76%和80.59%），研究结果表明黑木耳对铅中毒大鼠具有良好的排铅作用，且通过其多组分协同作用达到促排铅效果。

Elimination of lead by Auricularia auricular and its extracts was investigated using a preventive, high-lead rat model. Lead content and lead clearance rates in the blood, brain, liver, kidney, femur, urine, and feces of experimental groups treated with A. auricular and its various extracts were analyzed. The results showed that A. auricular could decrease lead content in the femur, blood, liver, kidneys and brain of lead-poisoned rats (P＜ 0.05), with clearance rates of 28.61%, 59.94%, 59.64%, 15.84%, and 29.41%, respectively. The A. auricular ethanol extract decreased lead content in blood (clearance rate: 63.47%) and increased lead content in urine (clearance rate: -55.45%); aqueous extract caused an increase in lead content in feces (clearance rate: -26.60%). Moreover, the extract residue showed a decrease in lead content in the femur, liver, kidneys, and brain (clearance rates: 49.82%, 74.21%, 74.76%, and 80.59%, respectively). These results indicate that A. auricular exerts good lead-eliminating effects in lead-poisoned rats, achieved by the synergistic action of its multiple components.

国家科技支撑计划课题（2009BADB7B06）