本研究对韩国传统饮品太明清(TMC)对扑热息痛所致小鼠肝损伤的保护作用进行了研究，ICR小鼠连续14 d灌胃给予低（100 mg/kg）、中（250 mg/kg）、高（500 mg/kg）三个剂量的太明清及阳性药物水飞蓟素（100 mg/kg）后，腹腔注射扑热息痛（800 mg/kg）建立动物急性肝损伤模型，动物处死后取血液和脏器测定各项指标。相对于模型对照组，太明清实验组的肝指数明显降低。三个剂量的太明清均明显降低血清谷丙转氨酶（ALT），谷草转氨酶（AST），碱性磷酸酶（ALP），甘油三酯（TG），尿素氮（BUN）水平，提高血清总胆固醇（TC），白蛋白（ALB）水平（p<0.05）。且三个剂量呈现了一定的量效关系。其中太明清高剂量组对小鼠肝损伤的保护效果最佳，仅次于阳性药物水飞蓟素组（p<0.05）。另外，从小鼠肝脏病理图来看，相对于模型对照组，太明清实验组对炎症及肝细胞坏死有明显改善。可见太明清对扑热息痛所致小鼠肝损伤具有较好的保护作用。

The present study investigated the protective effect of Taemyeongcheong (TMC; Korean traditional beverage) against acetaminophen (APAP)-induced liver damage in mice. ICR mice were administrated low dose (100 mg/kg), medium dose (250 mg/kg), and high dose (500 mg/kg) TMC as well as silymarin (S; positive control) by gavage for 14 consecutive days. An animal model of acute liver failure was established by intraperitoneal injection of APAP (800 mg/kg) in mice. After the mice were euthanized, their blood and organs were collected and measured for each indicator of hepatic injury. Compared with the control group, the indicators of hepatic injury for TMC group were significantly lower. All three doses of TMC could significantly reduce the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglycerides (TG), and blood urea nitrogen (BUN), and increase the levels of total cholesterol (TC) and albumin (ALB) (p < 0.05). In addition, a dose-effect relationship was observed with the three doses, among which the high dose TMC group showed a significant protective effect against hepatic injury and ranked second to the positive control, silymarin group (p < 0.05). According to the liver pathological images, inflammation and liver cell necrosis were significantly reduced in TMC group compared with the control group. Therefore, TMC had a moderate protective effect on APAP-induced liver damage in mice.

重庆高校创新团队建设计划资助项目（KJTD201325）