本文利用静电纺丝技术将可生物降解的聚乙烯醇(PVA)和具有良好抗菌作用的肉桂精油纺成抗菌纳米纤维材料。溶液组成及纺丝工艺参数会影响纤维直径的分布，进而影响材料的抗菌性能。因此，我们首先考察了不同质量浓度的PVA和β-环糊精(β-CD)对纤维直径分布的影响。借助扫描电镜对制备的纳米纤维形貌进行观察，发现最适的PVA及β-CD的质量浓度分别为6%和2%。在恒定电压下，利用SPSS分析接收距离和纺丝速率对纤维直径分布的影响。结果表明，接收距离对纤维直径的影响更为显著，而纺丝速率影响相对较小，适宜的纺丝工艺参数为电压15 kV，纺丝速率0.4 mL/h, 接收距离14 cm。在上述优化条件下，得到的纳米纤维直径分布均匀、形貌良好，有利于提高其抗菌活性。

Biodegradable polymer of polyvinyl alcohol (PVA) and cinnamon essential oil with a good antimicrobial effect were successfully electrospinned into antimicrobial nanofiber film in this study. The solution composition and electrospinning parameters had significant effect on the distribution of fiber diameter，leading to the variation of antimicrobial property of nano-material. Therefore, we first investigated the effect of PVA and β-cyclodextrin (β-CD) concentrations on the fiber diameter distribution. SEM was applied to observe the morphology of the nanofibers, and the optimal mass concentration of PVA and β-CD was found to be 6% and 2%, respectively. SPSS methodology was used to analyze the effect of the flow rate and distance on the diameter distribution under constant voltage condition The results showed that the distance had more remarkable influence on the nanofiber diameter than that of flow rate. The optimal electrospinning conditions were: voltage 15 kV, flow rate 0.4 mL/h and distance 14 cm. Under the above-mentioned optimal conditions, the diameters of the resulting nanofibers were equally distributed, and the nanofiber film had a good morphology, which could enhance the persistence of its antimicrobial ability.

国家自然科学基金资助项目(31071559)；新世纪优秀人才支持计划项目(NCET-11-0161，NCET-10-0367)；广东省天然产物绿色加工与产品安全重点实验室开放基金资助项目(201207)