研究尖顶羊肚菌活性提取物降血压作用及其机制，为尖顶羊肚菌的进一步开发应用提供实验依据。本研究通过注射N-硝基-L-精氨酸（L-NNA）建立大鼠高血压模型，分别用50、100、200 mg/kg?d（低、中、高剂量）的尖顶羊肚菌活性提取物（BEMC）灌胃高血压模型大鼠，观察其对大鼠收缩压、心率、体重、心指数、肝指数、脑指数、肾指数和血清中血管紧张素Ⅱ（ANG-Ⅱ）、一氧化氮（NO）和尿素氮（BUN）含量的影响。结果表明，与高血压模型组相比，低、中、高剂量组大鼠的收缩压分别降低了17.79%、6.99%和17.24%。低剂量组大鼠的血清NO含量增加了6.79%。中剂量组大鼠肾指数增加了5.16%，肝指数分别增加了4.89%，血清BUN含量减少了10.06%。低、中剂量组大鼠的血清ANG-Ⅱ含量分别减少了10.98%和27.29%，心率分别降低了7.51%和5.26%，心指数分别增加了7.66%和9.75%。尖顶羊肚菌活性提取物具有良好的降血压作用。

The antihypertensive effect of bioactive extracts from Morchella conica (BEMC) was studied in order to provide a theoretical basis for further exploitation of M. conica. The rats were intraperitoneally injected with L-NNA to settle the hypertensive model, and were orally administrated with different doses of the BEMC (50 mg/kg, 100 mg/kg and 200 mg/kg per day) for 28 d. Systolic blood pressure, heart rate, weight, heart index, liver index, brain index, kidney index and the contents of serum angiotensin II (AngⅡ), nitro oxide (NO) and blood urea nitrogen (BUN) were examined to evaluate antihypertensive effect of BEMC. Compared with the model group, the systolic blood pressures of the rats with the above-mentioned doses of BEMC were decreased by 17.79%, 6.99% and 17.24%, respectively. For the rat at 100 mg/kg dose of BEMC The level of serum NO of the rats at 50 mg/kg dose of BEMC was increased by 6.79%. The levels of kidney index, liver index and serum BUN of the rats were severally decreased by 5.16%, 4.89%, and 10.06%, respectively. And for that with low and middle dosages of BEMC (50 mg/kg and 100 mg/kg), the levels of serum AngⅡof the rats were severally decreased by 10.98% and 27.29%, respectively. And the levels of heart rate of the rats were severally decreased by 7.51% and 5.26%, respectively. In addition, the levels of heart index of the rats were severally decreased by 7.66% and 9.75% , respectively.

广州市科技计划项目（2012J4300129）