多肽-锌配合物是一种具有多种生物功能活性的新型有机金属化合物，该配合物主要来源于三个方面：一是通过人工制备的多肽与Zn2+的配合作用合成多肽-锌配合物，二是通过动植物蛋白质酶解获取的多肽与Zn2+的配合作用合成多肽-锌配合物，三是从动植物组织中直接提取多肽-锌配合物。由于构成多肽-锌配合物的配基多肽的不同而具有不同的组成和结构，从而体现出不同的生物功能活性，包括抗菌抑菌、生理机能调节和免疫调节、抗氧化作用等。本文就国内外对多肽-锌配合物的生物功能活性及安全性的研究现状、最新研究进展及未来研究方向等方面进行综合阐述。提出今后应加强对其毒理学特性和应用安全性方面的研究，以推进多肽-锌配合物的实际应用和产业化开发。

Peptide chelated zinc is a new organic metal compound with various bioactivities. It is mainly prepared by three methods, including synthesis with zn2+ and artificial peptide, synthesis of zn2+ and natural peptide by enzymolysis of plant and animal protein, and extraction from plant and animal tissue. Due to the difference of peptide ligands, the peptide chelated zinc showed varied structure and bioactivities including antibacterial and bacteriostasis effect, regulations of physiological functions and immune, and antioxidation.. The recent researches of bioactivities and safety of peptide chelated zinc were reviewed in this research. Suggestion were proposed on more investigation of elative toxicology and applying safety of this compound, to promote the potential industrial application of peptide chelated zinc

广州市科技计划项目（12C12011620），广州市科信局重大专项（2012Y2-00008）