为了研究富硒大豆低聚肽在降血压方面的作用，本研究采用5周龄SD雄性大鼠60只，随机分为4组，按设计进行饲喂实验，测定各试验大鼠的体重和血压，饲喂4周，停喂次日处死所有大鼠，测定血清和肺组织中ACE活力及血清中K、Na、Se的含量。结果显示：富硒大豆低聚肽能促进试验大鼠的体重增加，降低大鼠血清中ACE活性，但对肺组织ACE活性无显著影响，能导致大鼠血清中Na离子浓度下降、Se含量增加。说明富硒大豆低聚肽具有降低SHR血压的作用，这种作用是Se和大豆低聚肽共同作用的结果，除与ACE活力被抑制有关外，还可能与导致大鼠体内Na+浓度下降、Se含量增加有关。

To study the effect of Se-riched soybean oligopeptides in lowering blood pressure, 90 male SD rats of 5 weeks old were randomly divided into 4 groups and had been fed according to the design. The body weight and blood pressure of those rats were determined at the weekend. After feeding for 4 weeks, all of the rats were sacrificed at the next day of stopping feeding and the ACE activity in serum and lung tissue, as well as the content of K, Na and Se in serum were measured. Results showed that Se-riched soy oligopeptides can promote the body weight of the experimental rats, reduce the ACE activity in serum, but showed little effect on the ACE activity in lung tissue. Se-riched soy oligopeptides can l decrease concentration of Na ion in serum and increase the content of Se in serum, indicating that they can decrease blood pressure of SHR which were due to the combined effects of Se and soy oligopeptides. Except that the ACE activity has been inhibited, the decreased of Na+ and the increase of the content of Se may also lead to the decrease of the blood pressure of SHR.

清远职业技术学院院级课题（KY090002）