建立了SPE-SIM-GC-MS测定液态调味料中4-甲基咪唑的新方法。对影响4-甲基咪唑萃取效率的诸因素如溶液的pH、洗脱溶剂和洗脱溶剂的体积等进行了优化。在最佳的萃取条件下，该方法对4-甲基咪唑的检出限为7.27 μg/kg；相关系数和相对标准偏差（RSD, n=5）分别为0.99985和7.5%。将该方法用于实际样品中4-甲基咪唑的分析，其加标回收的回收率为80.3~86.2%。

A simple and sensitive method was developed for determination of 4-methylimidazole in liquid seasoning samples by solid phase extraction (SPE) with selected ion mass-gas chromatography mass spectrometry (SIM-GCMS). In this work, effects of solution pH, type and volume of elution solvents were investigated to optimize extraction conditions. Under the optimized SPE conditions, the relative standard deviation (RSD, n=5) for the samples was 7.5%. The coefficient of determination for calibration curve was 0.99985. The method detection limit was 7.27 μg/kg. The method was applied to real samples and the recovery of 80.3~86.2 % was obtained.

广东省质量技术监督局科技项目(2009ZZ09)