以马来酸酐和苯甲醇为原料，无水氯化铝为异构化催化剂，合成富马酸单苯甲酯。利用熔点测定、红外光谱和核磁共振氢谱分析对产品进行结构表征；采用单因素实验分别研究反应物摩尔比、酯化反应温度与时间、异构化催化剂、异构化催化剂用量对产物收率的影响。结果表明：以无水氯化铝为异构化催化剂、原料马来酸酐:苯甲醇:无水氯化铝配比为0.1 mol:0.1 mol:2 g、酯化反应温度60 ℃、反应时间3 h，此条件下富马酸单苯甲酯的收率可达74.5%。抑菌活性实验结果表明，富马酸单苯甲酯具有良好的抑菌活性。

Monobenzyl fumarate was synthesized from benzyl alcohol and maleic anhydride using anhydrous aluminum chloride as the catalyst. The reaction products were structurally identified by means of melting point measurement, Infrared spectrum (IR) and 1H-NMR. The effects of malor ratio reagents, esterification temperature and time, isomerization catalyst, and isomerization catalyst dosage on monobenzyl fumarate yield were studied. Anhydrous aluminum chloride was shown as the best isomerization catalyst and the optimal reaction conditions were determined as follows molar ratio of maleic anhydride to benzyl alcohol (for 2 g anhydrous aluminum chloride) 0.1/0.1, reaction temperature 60 ℃, reaction time 3 h under reflus condition and further reaction time 2 h after adding isomerization catalyst. Under such conditions, the yield of monobenzyl fumarate reached 74.5%. The experiment of antimicrobial activity showed that monobenzyl fumarate exhibited high anticimicrobial activity.

中央高校基本科研业务费专项资金资助（2012zm0070）