以MCM-41分子筛为催化剂，由D-葡萄糖酸制备D-葡萄糖酸-·-内酯。考察了反应温度、反应时间、催化剂用量以及催化剂循环使用次数对D-葡萄糖酸-·-内酯产率的影响。实验结果表明，MCM-41是制备D-葡萄糖酸-·-内酯较好的催化剂。最佳工艺条件为：催化剂用量为30%，反应温度80 ℃，反应时间2 h，D-葡萄糖酸-·-内酯产率达到90.39%。

D-Glucono delta-lactone was produced from D-Gluconic acid using molecular sieve MCM-41 as catalyst. Effects of various factors on D-Glucono delta-lactone yield, including reaction temperature, reaction time, catalyst dosage and recycling index of molecular sieve MCM-41, were discussed. Experimental results showed that molecular sieve MCM-41 was a better catalyst for preparation of D-Glucono delta-lactone. The optimum reaction condition was obtained as follow: catalyst dosage 30%, reaction temperature 80 ℃, and reaction time 2 h, under which D-Glucono delta-lactone yield was as high as 90.39%.

国家自然科学基金(50776035, U0733001)、教育部博士点基金项目(20070561038)、863计划项目(2007AA05Z408)、国家科技支撑计划项目(2007BAD34B01)和973计划项目(2010CB732201)